Biosafety considerations for attenuated measles virus vectors used in virotherapy and vaccination.

Last updated on 22-8-2019 by Anonymous (not verified)

Peer reviewed scientific article

English

SCIENSANO

Abstract:

Attenuated measles virus (MV) is one of the most effective and safe vaccines available, making it attractive candidate vector to prevent infectious diseases. Attenuated MV have acquired the ability to use the complement regulator CD46 as a major receptor to mediate virus entry and intercellular fusion. Therefore, attenuated MV strains preferentially infect and destroy a wide variety of cancer cells making them also attractive oncolytic vectors. The use of recombinant MV vector has to comply with various regulatory requirements, particularly relating to the assessment of potential risks for …

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