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Development of luminescent Mycobacterium avium subsp. paratuberculosis for rapid screening of vaccine candidates in mice37076

Last updated on 22-8-2019 by Anonymous (not verified)

Public Access

Published

Peer reviewed scientific article

DOI : http://dx.doi.org/10.1128/IAI.01521-05

Authors

Rosseels,V.; Virginie Roupie; D. Zinniel; Barletta,R.G.; K Huygen

Keywords

  1. 0
  2. a
  3. an
  4. Animals
  5. article
  6. Bacterial Vaccines
  7. BCG
  8. BCG Vaccine
  9. Belgium
  10. Brussels
  11. culture
  12. Development
  13. Female
  14. gene
  15. Genes
  16. genetics
  17. growth & development
  18. im
  19. immunology
  20. Institute
  21. IS
  22. IT
  23. journal
  24. Luciferases
  25. Luminescent Measurements
  26. M
  27. mice
  28. MODEL
  29. Mycobacterium
  30. Mycobacterium avium subsp.paratuberculosis
  31. Paratuberculosis
  32. Plasmids
  33. Print
  34. Research
  35. Research Support
  36. SB - IM
  37. SCREENING
  38. Species
  39. TESTING
  40. Transformation,Bacterial
  41. use
  42. vaccine
  43. vaccines

Abstract:

Mycobacterium avium subsp. paratuberculosis is a slowly growing mycobacterial species, requiring 6 to 8 weeks of culture before colonies can be counted visually. Here, we describe the development of luminescent M. avium subsp. paratuberculosis expressing luxAB genes of Vibrio harveyi and its use for vaccine testing in an experimental mouse model, replacing fastidious CFU counting by rapid luminometry
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