Development of an M2e-specific enzyme-linked immunosorbent assay for differentiating infected from vaccinated animals.

Last updated on 18-10-2022 by Anonymous (not verified)

Peer reviewed scientific article



Vaccination programs for the control of avian influenza (AI) in birds have restrictions because of some limited efficacy and the difficulty of discriminating between vaccinated and virus-infected poultry. We studied M2e, the highly conserved external domain of the influenza A M2 protein, as a potential differential diagnostic marker for influenza virus infection. The M2 protein is an integral membrane protein, scarcely present on virus particles, but abundantly expressed on virus-infected cells. M2e-specific enzyme-linked immunosorbent assays (ELISAs) for different avian influenza strains w…

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