DNA vaccines against tuberculosis.

Last updated on 22-8-2019 by Anonymous (not verified)

Peer reviewed scientific article



INTRODUCTION: Tuberculosis (TB) remains a major health problem and novel vaccination regimens are urgently needed.AREAS COVERED: DNA vaccines against TB have been tested in various preclinical models and strategies have been developed to increase their immunogenicity in large animal species. DNA vaccines are able to induce a wide variety of immune responses, including CD8(+) T-cell-mediated cytolytic and IFN-γ responses. DNA vaccination may be valuable in heterologous prime-boost strategies with the currently used bacillus Calmette-Guérin (BCG) vaccine. This approach could broaden the antig…

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