Functional elucidation of antibacterial phage ORFans targeting Pseudomonas aeruginosa

Last updated on 22-8-2019 by Anonymous (not verified)

Public Access


Peer reviewed scientific article



Immediately after infection, virulent bacteriophages hijack the molecular machinery of their bacterial host to create an optimal climate for phage propagation. For the vast majority of known phages, it is completely unknown which bacterial functions are inhibited or coopted. Early expressed phage genome regions are rarely identified, and often filled with small genes with no homology in databases (so-called ORFans). In this work, we first analysed the temporal transcription pattern of the N4-like Pseudomonas-infecting phages and selected 26 unknown, early phage ORFans. By expressing their e…

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