Impact of caspase-1/11, -3, -7, or IL-1/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.

Last updated on 27-11-2019 by Anonymous (not verified)

Public Access

Peer reviewed scientific article

English

SCIENSANO

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Abstract:

Rabies virus is a highly neurovirulent RNA virus, which causes about 59000 deaths in humans each year. Previously, we described macrophage cytotoxicity upon infection with rabies virus. Here we examined the type of cell death and the role of specific caspases in cell death and disease development upon infection with two laboratory strains of rabies virus: Challenge Virus Standard strain-11 (CVS-11) is highly neurotropic and lethal for mice, while the attenuated Evelyn-Rotnycki-Abelseth (ERA) strain has a broader cell tropism, is non-lethal and has been used as an oral vaccine for animals. I…

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