The Major Envelope Glycoprotein of Murid Herpesvirus 4 Promotes Sexual Transmission.

Last updated on 3-1-2022 by Anonymous (not verified)

Public Access

Published

Peer reviewed scientific article

English

Abstract:

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp150 is redundant for host entry, and , it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the female genital tract after nasal infection but is poorly released from vaginal epithelial cells and fails to pass fr…

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