MALDI-TOF mass spectrometry: revolutionising clinical laboratory diagnosis of mould infections

Last updated on 23-8-2019 by Anonymous (not verified)

Public Access


Peer reviewed scientific article



Clinical diagnosis of mould infections currently involves complex species identification based on morphological criteria, which is often prone to error. Employing an extensive mould species reference spectral library (up to 2,832 reference spectra, corresponding to 708 strains from 347 species), we assessed the extent to which MALDI-TOF mass spectrometry (MALDI-TOF MS) enhanced the accuracy of species identification. MALDI-TOF MS data were validated against morphology- and DNA sequencing-based results using 262 clinical isolates collected over a four-month period in 2013. The implementation…

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