Last updated on 23-8-2019 by Anonymous (not verified)
Public Access
Published
Authors
Frealle,E.; Noel,C.; Nolard,N.; Symoens,F.; Felipe,M.S.; Dei-Cas,E.; Camus,D.; Viscogliosi,E.; Delhaes,L.Keywords
Abstract:
Superoxide dismutases (SODs), which provide protection against oxidative stress, exhibit an essential role for fungal cell survival, especially during host invasion. Here, 20 partial SOD sequences from 19 pathogenic fungi were determined and aligned with 43 homologous fungal sequences from databases. All sequences encoded tetrameric manganese (Mn)-containing SODs showing predicted cytosolic or mitochondrial subcellular localization. Numerous fungi possessed both cytosolic and mitochondrial MnSODs in addition to the mainly cytosolic copper/zinc isozyme. Moreover, MnSOD sequence variability w…