Last updated on 23-8-2019 by Anonymous (not verified)
Public Access
Published
Authors
Aline Baldo; Monod,M.; Mathy,A.; Cambier,L.; Bagut,E.T.; Defaweux,V.; Symoens,F.; Antoine,N.; Mignon,B.Keywords
Abstract:
Dermatophytes are keratinophilic fungi that can be pathogenic for humans and animals by infecting the stratum corneum, nails, claws or hair. The first infection step consists of adherence of arthroconidia to the stratum corneum. The mechanisms and the kinetics of adherence have been investigated using different in vitro and ex vivo experimental models, most notably showing the role of a secreted serine protease from Microsporum canis in fungal adherence to feline corneocytes. After germination of the arthroconidia, dermatophytes invade keratinised structures that have to be digested into sh…