Modulation of early beta-defensin-2 production as a mechanism developed by type I Toxoplasma gondii to evade human intestinal immunity36564

Last updated on 23-8-2019 by Anonymous (not verified)

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Peer reviewed scientific article


We investigated the early innate immune responses induced in human intestinal epithelial cells (IEC) by the three defined Toxoplasma gondii genotype strains. Transcriptome analysis revealed that among differentially expressed genes, beta-defensins distinguished the most IEC infected by fast- or slow-replicating T. gondii genotypes. Although beta-defensin 1 and 3 genes were not expressed in host cells at early time points postinfection, the slow-replicating type II and III parasites induced high levels of beta-defensin 2 gene expression. Notably, no beta-defensin 2 gene expression occurred e…

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