Multivalent binding of herpesvirus to living cells is tightly regulated during infection.

Last updated on 1-10-2018 by Pierre Daubresse

Public Access

Published

Peer reviewed scientific article

English

Keywords

Abstract:

Viral infection, initiated by the landing of a virion on a cellular surface, is largely defined by the preliminary interactions established between viral particles and their receptors at the cell surface. While multiple parallel interactions would allow strong virus attachment, a low number of bonds could be preferred to allow lateral diffusion toward specific receptors and to promote efficient release of progeny virions from the cell surface. However, so far, the molecular mechanisms underlying the regulation of the multivalency in virus attachment to receptors are poorly understood. We in…

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