PCNA and Ki67 proliferation markers as criteria for prediction of clinical behaviour of melanocytic tumours in cats and dogs.

Last updated on 23-8-2019 by Anonymous (not verified)

Peer reviewed scientific article



Melanocytic tumours in domestic animals vary from benign to highly malignant. Diagnosis and prognosis are mainly based on the somewhat uncertain interpretation of cytological signs of malignancy in histological sections. The purpose of the present retrospective study was to compare the accuracy of prognosis based on the classical morphological criteria with that provided by quantitative computerized analysis of proliferation-associated antigens. Twenty-seven melanocytic tumours (20 canine and seven feline) from 24 animals (20 dogs and four cats) were examined. These comprised eight tumours …

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