Last updated on 23-8-2019 by Anonymous (not verified)
Peer reviewed scientific article
English
SCIENSANO
Authors
Ryelandt, M; D De Wit; A Baz; Vansanten, G; Olivier J Denis; F Huetz; Nisol, F; Macedo-Soares, F; S Barcy; Brait, MKeywords
Abstract:
The immune response of A/J mice against p-azophenylarsonate (Ars)-keyhole limpet hemocyanin (KLH) is characterized by the dominance, late in primary and during the secondary, of a recurrent idiotype called CRIA, encoded by a canonical combination of Ig gene segments. In this study, A/J mice were given Ars coupled to deaggregated human gamma globulins (dHGG) within 24 h after delivery. The offsprings from these mice were then exposed as adults to Ars-KLH. These animals developed an unusual immune response. The level of anti-Ars antibodies was nearly normal but a dramatic shift in repertoire …