Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2'-C-methylcytidine in severe combined immunodeficient mice.

Last updated on 2-10-2019 by Anonymous (not verified)

Peer reviewed scientific article

SCIENSANO

Abstract:

Recent European contingency plans envisage emergency vaccination as an animal-friendly control strategy for foot-and-mouth disease (FMD). Anti-viral drugs may be used as an alternative or complementary measure. We here demonstrate that the nucleoside analogue 2’-C-methylcytidine (2’CMC) protects severe combined immunodeficient (SCID) mice against lethal FMD virus infection. In brief, SCID mice were inoculated with serotype A FMD virus and treated for five consecutive days with 2’CMC. All 15 treated mice remained healthy until the end of the study at 14 days post-infection (dpi). At that tim…

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