In silico methods for chromosome damage

Last updated on 25-11-2022 by Ilse Van Overmeire

Scientific book or chapter

English

SCIENSANO

Keywords

Abstract:

Due to the link with serious adverse health effects, genotoxicity is an important toxicological endpoint in each regulatory setting with respect to human health, including for pharmaceuticals. To this extent, a compound’s potential to induce gene mutations as well as chromosome damage needs to be addressed. For chromosome damage, i.e. the induction of structural or numerical chromosome aberrations, several in vitro and in vivo test methods are available. In order to rapidly collect toxicological data without the need for test material, several in silico tools for chromosome damage have been…

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