Urinary nicotine metabolites: usefulness as biomarkers of smoking status

Last updated on 8-4-2021 by Jill Alexandre

Public Access


Scientific poster, presentation or proceeding



Aims Nicotine is metabolised to cotinine (COT) and further to trans-3’-hydroxycotinine (HCOT) by the cytochrome P450 CYP2A6 enzyme. It has been demonstrated that the ratio of HCOT to COT is an index of CYP2A6 activity, thus a marker of nicotine metabolism, with higher ratios indicating faster metabolism. Evidence shows that the ratio, in urine, saliva or plasma, could predict responses to smoking cessation medication and guide pharmacotherapy. Since the literature about the association between this ratio and the cigarettes smoked per day (cpd) is not uniform, our aim was to investigate thi…

Associated health topics:

QR code

QR code for this page URL