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Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome.
Maeyer, Marc; Aertsen, Abram; Noben, Jean-Paul; Luisi, Ben F; Lavigne, Rob Source: Elife, Volume 5 (2016) Keywords: Binding Sites Crystallography, X-Ray Endoribonucleases Host-Parasite Interactions Models, ...
Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.
Issue 10, p.5186-93 (2012) Keywords: Amidohydrolases Antitubercular Agents Crystallography, X-Ray Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Pyrazinamide Abstract: Pyrazinamide (PZA) ...
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
Keywords: 0 a Administration,Oral Agent Agents Animals antagonists & inhibitors Antibiotic Antitubercular Agents article Cell Line chemical synthesis chemistry Combination Control Crystallography,X-Ray de ...
Crystal structure of a dimeric oxidized form of human peroxiredoxin 5.
Source: J Mol Biol, Volume 337, Issue 5 (2004) Keywords: Crystallization Crystallography, X-Ray Dimerization Disulfides Dithiothreitol Electrophoresis, Polyacrylamide Gel Humans Mass Spectrometry Models, ...
Viral interference of the bacterial RNA metabolism machinery.
a unique interaction between a protein encoded by the giant myovirus phiKZ and the Pseudomonas aeruginosa RNA degradosome. Crystallography, site-directed mutagenesis and interactomics approaches revealed ...