Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome.

Last updated on 23-8-2019 by Anonymous (not verified)

Public Access


Peer reviewed scientific article



In all domains of life, the catalysed degradation of RNA facilitates rapid adaptation to changing environmental conditions, while destruction of foreign RNA is an important mechanism to prevent host infection. We have identified a virus-encoded protein termed gp37/Dip, which directly binds and inhibits the RNA degradation machinery of its bacterial host. Encoded by giant phage фKZ, this protein associates with two RNA binding sites of the RNase E component of the Pseudomonas aeruginosa RNA degradosome, occluding them from substrates and resulting in effective inhibition of RNA degradation a…

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