Search results - 5 results
Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials.
safety. By combining in silico predictions with existing in vitro and in vivo genotoxicity data from publicly available literature sources and results from in vitro gene mutation experiments, the 106 study ...
Assessment of estrogenic compounds in paperboard for dry food packaging with the ERE-CALUX bioassay
a dry food migration experiment. By measuring an overall estrogenic activity, known and unknown estrogenic chemicals and mixture effects are taken into account and the data are compared to molecule ...
A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment
5 known positive and 5 known negative test compounds for genotoxicity was evaluated. In addition, 2 compounds with debatable genotoxicity data were tested to explore how the qPCR array would classify these. ...
Coatings in food contact materials: Potential source of genotoxic contaminants?
two structure-activity relationship (SAR) software programs. For substances yielding structural alerts in both models, genotoxicity data were collected from previous European evaluations in a non- FCM ...
Study of the possible migration risks of food contact materials for children under 3 years
etc.) that could not be identified before were elucidated here. Additionally, the same extracts were analysed also by LC- QTOF- MS under MSE mode. The full-spectrum accurate mass data of both ...