Search results - 70 results

2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.

the search for novel bio-active compound classes against this disease is of utmost importance. As a result of a high intrinsic tolerance of the etiological agent, Mycobacterium tuberculosis, towards ...

Biological evaluation of diazene derivatives as anti-tubercular compounds.

generation and spread of drug resistant strains, a problem exacerbated by co-infection with HIV demands further efforts in the investigation of novel classes of anti-tubercular compounds. A library of eight ...

The eukaryotic linear motif resource ELM: 10 years and counting.

accessible guide to the biology and function of linear motifs. The current version of ELM contains ∼200 different motif classes with over 2400 experimentally validated instances manually curated from >2000 ...

Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine36497

Eur.J.Med.Chem., Volume 67, Number 110, p.98- 110 (2013) Keywords: acute toxicity antibiotics Cleistopholine Pyridinium ylids Sampangine Tuberculosis Abstract: Identification and investigation of novel classes and ...

Using multiple measures of inequalities to study the time trends in social inequalities in smoking.

4, p.546-51 (2013) Keywords: ADOLESCENT Adult Aged Belgium Educational Status Female Humans Longitudinal Studies Male middle aged Poverty Risk Factors sex factors SMOKING social class Young adult ...

Characterization of methicillin-resistant non-Staphylococcus aureus staphylococci carriage isolates from different bovine populations.

multidrug-resistance gene cfr. SCC mec cassettes of type III predominated (n = 46); another 40 SCC mec cassettes harboured a class A mec complex without identifiable ccr complex; type IV a, type V and several other ...

An update on vaccines for tuberculosis- there is more to it than just waning of BCG efficacy with time.

of MHC class I restricted responses. Prime-boost strategies based on the actual BCG vaccine may not be sufficient to overcome this hurdle. The use of plasmid DNA vaccination might offer a solution. ...

A validated GC-MS method for the determination and quantification of residual solvents in counterfeit tablets and capsules.

Temperature Time Factors Abstract: A fast headspace GC- MS method was developed and validated for the detection and quantification of residual solvents of all three ICH-classes in counterfeit tablets and ...

Chemometrics and chromatographic fingerprints to discriminate and classify counterfeit medicines containing PDE-5 inhibitors.

differences between the samples of the different classes of counterfeits as defined by the Dutch National Institute for Public Health and the Environment (RIVM). In a second part the revealed differences ...

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