Search results - 8 results
VERMEER FCM: A tool integrating exposure and hazard modelling for chemicals migrating from food contact materials
predicted by a recently developed migration model, whereas hazard predictions for genotoxicity, subchronic toxicity, reproductive and developmental toxicity and carcinogenicity are provided by QSAR models ...
Guidance in selecting analytical techniques for identification and quantification of non-intentionally added substances (NIAS) in food contact materials (FCMS)
different results and it can be difficult to make meaningful comparisons. The initial approach was to attempt to prepare a prescriptive methodology but as this proved impossible; this paper develops ...
Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials.
testing, such strategies should respect the 3R principles (Replacement, Reduction, Refinement). In the present study, a strategy based on non-animal approaches was developed to prioritize non-evaluated ...
A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment
regulatory accepted batteries for in vitro genotoxicity testing is recognized, they result in a high number of false positives. This has a major impact on society and industries developing novel compounds ...
Coatings in food contact materials: Potential source of genotoxic contaminants?
coatings has not (recently) been evaluated. Since detailed evaluation of all compounds is not feasible, a pragmatic approach was developed to identify substances with a potential concern for human health. ...
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances.
methods such as in silico (i.e. computational) techniques gain more and more importance. In the current study, a new prioritization strategy for identifying potentially mutagenic substances was developed ...
Study of the possible migration risks of food contact materials for children under 3 years
simulant with a mixture of common organic compounds (Chapter 4.1) was optimised. To develop a robust and general method, a mixture of 17 chemicals (identified in the literature as possible migrants from FCM ...
Development and application of a non-target extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS.
Accepted (2015) Keywords: alternatives analysis Antioxidant Antioxidants application AS Babies baby bottle Baby bottles Bisphenol-A chemicals comparing CONTACT Context Development differences food food ...