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The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
aethiops Enterovirus B, Human HeLa Cells Humans Poliovirus RNA-Dependent RNA Polymerase Viral Proteins Abstract: The genus Enterovirus of the family Picornaviridae contains many important human pathogens ...
Study of the virulence of serotypes 4 and 9 of African horse sickness virus in IFNAR(-/-), Balb/C and 129 Sv/Ev mice.
belongs to the family Reoviridae, genus Orbivirus. Recent studies have focused on the interferon-α/β receptor knock-out mice (IFNAR (-/-)) as a small animal laboratory for the development of AHSV vaccines. ...
Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
swine fever virus (CSFV) with an EC50 of 0.33±0.25μM. BBP / CSFA-0 proved in vitro inactive against the hepatitis C virus, that belongs like BVDV and CSFV to the family of Flaviviridae. Modification of ...