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First Belgian Report of Ertapenem Resistance in an ST11 Klebsiella Pneumoniae Strain Isolated from a Dog Carrying blaSCO-1 and blaDHA-1 Combined with Permeability Defects
the presence of blaSCO-1 and blaDHA-1, combined with permeability defects caused by point mutations in an outer membrane porin (OmpK37). The presence of the blaSCO-1 gene on a conjugative IncFIB(K) ...
Evaluation of the pathogenicity of West Nile virus (WNV) lineage 2 strains in a SPF chicken model of infection: NS3-249Pro mutation is neither sufficient nor necessary for conferring virulence.
Chickens Genotype Mutation Poultry Diseases Specific Pathogen-Free Organisms Viremia virulence West Nile Fever West Nile virus Abstract: Lineage 2 West Nile virus (WNV) strains were reported for the first ...
Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.
NCX1. RESEARCH DESIGN AND METHODS: Biologic and morphologic methods (Ca(2+) imaging, Ca(2+) uptake, glucose metabolism, insulin release, and point counting morphometry) were used to assess β-cell function ...
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
fever. LZ37 inhibits BVDV replication at a time point that coincides with the onset of intracellular viral RNA synthesis. Drug-resistant mutants carried the F224Y mutation in the viral RNA-dependent RNA ...
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
microM, 5 +/- 1 microM, and 2.3 +/- 0.3 microM, respectively. AG110 proved inactive against the hepatitis C virus and a flavivirus. AG110 inhibits BVDV replication at a time point that coincides with the ...
Point mutations in an infectious bovine viral diarrhoea virus type 2 cDNA transcript that yields an attenuated and protective viral progeny.
(2005) Keywords: Animals Bovine Virus Diarrhea-Mucosal Disease Cattle Diarrhea Viruses, Bovine Viral DNA, Complementary Point Mutation Vaccination Vaccines, Attenuated Viral Vaccines virulence Abstract: An ...
Classical swine fever virus is genetically stable in vitro and in vivo.
bottleneck, a single point mutation was observed in the E2 gene. Additionally, only four nucleotide substitutions were observed when the genome of a virus obtained after 96 cell passages in persistently ...
Characterization of In Vivo acquired resistance of Mycoplasma hyopneumoniae to macrolides and lincosamides.
rDNA. Therefore, high MIC s were observed for all strains, although the MIC s for the resistant strain were clearly increased. An additional, acquired A 2058 G point mutation was found in the 23S rRNA ...
Resistance mechanism against fluoroquinolones in Mycoplasma hyopneumoniae field isolates.
Fluoroquinolones Genes, Bacterial Microbial Sensitivity Tests Mycoplasma hyopneumoniae Point Mutation polymerase chain reaction Sequence Analysis, DNA Swine Abstract: The quinolone resistance-determining regions ...
Replicative fitness recuperation of a recombinant murine norovirus- reciprocity of genetic shift and drift.
Source: J Gen Virol, Volume 101, Issue 5 (2020) Keywords: Animals Caliciviridae Infections Cell Line DNA, Complementary Follow-Up Studies Genetic Drift Genome, Viral mice Norovirus Point Mutation RAW 264.7 ...