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Discovery and Development of an Advanced Lead for the Treatment of African Trypanosomiasis.

identified following screening against the most relevant trypanosome species. Selected hit compounds were extensively tested for metabolic stability, potency in mouse models for the various species, ...

Sphaeropsidin A C15-C16 Cross-Metathesis Analogues with Potent Anticancer Activity.

Drug Drug Screening Assays, Antitumor Humans Molecular Structure Pyrenes Structure-Activity Relationship Abstract: We recently discovered that sphaeropsidin A (SphA), a fungal metabolite from Diplodia ...

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