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Cytokine and immunoglobulin isotype profiles during CP7_E2alf vaccination against a challenge with the highly virulent Koslov strain of classical swine fever virus.
vaccine and challenge strain. Interestingly, IFN-γ enhancement and persistent high IgG2 levels suggested an important role of cell-mediated immunity in long-term protection against CSFV induced by CP7_E2alf ...
Sustained stimulation and expansion of Tregs by IL2 control autoimmunity without impairing immune responses to infection, vaccination and cancer.
Regulation Gene Transfer Techniques HEK293 Cells Humans INFECTION Interleukin-2 Lymphocyte Activation Male mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Neoplasms T-Lymphocytes, Regulatory Time ...
Increasing the Vaccine Potential of Live M. bovis BCG by Coadministration with Plasmid DNA Encoding a Tuberculosis Prototype Antigen.
B-cell responses were observed with this protocol in C57BL /6 mice when compared to the administration of only BCG or in combination with an empty pDNA vector, as measured by Th1-type spleen cell cytokine ...
Biological evaluation of diazene derivatives as anti-tubercular compounds.
examined for acute cell toxicity on a murine macrophage like monocyte cell line J774 A.1 in which the cell viability was reduced by 50% at concentrations ranging from 7.4 μg/mL to 20.7 μg/mL. Neither of the ...
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
Agents Cell Line Cysteine Endopeptidases Drug Evaluation, Preclinical Genes, Reporter Humans Luciferases, Firefly Picornaviridae Protease Inhibitors Viral Proteins Abstract: Proteolytical cleavage of the ...
Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials.
10(5) (23·2-53·5), respectively, in the control arm. Rate ratios did not differ by cancer stage, but were lower for adenocarcinoma (0·31, 0·14-0·69) than for squamous-cell carcinoma (0·78, 0·49-1·25). The ...
Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: a meta-analysis.
the following selection criteria: a cervical cell sample was self-collected by a woman followed by a sample taken by a clinician; a high-risk HPV test was done on the self-sample (index test) and ...
Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes.
metabolic activation), we observed significant increases in the frequencies of micronucleated binucleated cells (MNBC s) for some TiO2 NM s and for two MWCNT s, although no clear dose-response relationships ...
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK651
Agents agonists an Animals article AS association Biology Brain Neoplasms cancer Cell Cell Cycle Cell Proliferation cells Cells,Cultured CHILDREN Clinical clinical trial Clinical trials drug effects effect ...
Engineering nucleases for gene targeting: safety and regulatory considerations.
applicable from single-celled protozoa to human, including several species of economic importance. Along with the fast progress in NBGT and the increasing availability of customized nucleases, more data are ...