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Eight years after an international workshop on myotonic dystrophy patient registries: case study of a global collaboration for a rare disease.
1 (2018) Keywords: Clinical trials Myotonic dystrophy REGISTRIES Trial readiness Abstract: BACKGROUND: Myotonic Dystrophy is the most common form of muscular dystrophy in adults, affecting an estimated 10 ...
Application of whole genome data for in silico evaluation of primers and probes routinely employed for the detection of viral species by RT-qPCR using dengue virus as a case study.
more attention in their development process. Our approach is also available as a public tool, and demonstrates how utilizing genomic data can provide meaningful insights in an applied public health ...
Relationship between mold exposure, specific IgE sensitization, and clinical asthma: A case-control study.
associated with asthma severity. However, regardless of the sensitization, exposure to A fumigatus and Penicillium spp in dust was linked to an increased risk of severe asthma. CONCLUSION: The harmful nature ...
Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice.
had no effect. Disease development was also delayed in mice treated with the MALT1 protease inhibitor mepazine, and in knock-in mice expressing a catalytically inactive MALT1 mutant protein, showing an ...
Clonal Spread of Candida glabrata Bloodstream Isolates and Fluconazole Resistance Affected by Prolonged Exposure: a 12-Year Single-Center Study in Belgium.
(10.7%) of the isolates. An analysis of the antifungal consumption data revealed that recent prior exposure to fluconazole increased the risk to be infected by a resistant strain. In particular, the ...
Risk to human and animal health related to the presence of 4,15-diacetoxyscirpenol in food and feed
established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panel considered these data as informative for the ...
Neonatal factors predictive for respiratory and gastro-intestinal morbidity after esophageal atresia repair.
Multinomial logistic regression showed that prematurity (p = 0.018) and VACTERL association (p = 0.003) were significant factors of complications. CONCLUSION: Prematurity is an important predictive factor for ...
Risk factors and impact of allergic bronchopulmonary aspergillosis in Pseudomonas aeruginosa-negative CF patients.
a facilitating factor for ABPA. ABPA causes a significant increase in bronchial damage. In patients with ABPA, further bronchial damage can be controlled by an increase in hospitalization days and use of IV ...
Farming, Q fever and public health: agricultural practices and beyond.
have provided new dynamics for transmission. This article provides a general overview of some factors that influence the epidemic potential of a zoonotic disease, Q fever. As an example of a disease ...
Y-box-binding protein 1 supports the early and late steps of HIV replication.
levels. More precisely, using quantitative PCR and an in vivo nuclear import assay with fluorescently labeled viral particles, we showed that YB-1 knockdown leads to a block between reverse transcription ...