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In vitro antigenotoxic activity, in silico ADME prediction and protective effects against aflatoxin B1 induced hepatotoxicity in rats of an Erythrina latissima stem bark extract
effect of ELBE against AFB1 induced genotoxicity in the Vitotox assay after metabolic activation was confirmed (IC50 of 44.32 μg/ml), followed by evaluation of its inhibitory effect on hepatotoxicity in ...
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK651
suggest that although AICAR and metformin are potent AMPK-independent antiproliferative agents, physiological AMPK activation in glioma may be a response mechanism to metabolic stress and anticancer agents ...
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
Keywords: 0 a Administration,Oral Agent Agents Animals antagonists & inhibitors Antibiotic Antitubercular Agents article Cell Line chemical synthesis chemistry Combination Control Crystallography,X-Ray de ...
Naegleria gruberi metabolism
0 Absence Agent Agents an Antiprotozoal Agents article AS Belgium Brussels Carbohydrate Carbohydrates Carbon data de disease Diseases DRUG drug effects drugs electronic Ethanol genetics Genome genomic Humans ...
Pharmacokinetics of a loading dose of amikacin in septic patients undergoing continuous renal replacement therapy87
Int.J.Antimicrob.Agents, Volume 37, Issue 6, Number 535, p.531- 535 (2011) Keywords: 0 a administration & dosage Adult Aged Aged,80 and over Agent Agents Amikacin Anti-Bacterial Agents Antimicrobial article AS at ...
Population pharmacokinetic modeling and optimal sampling strategy for Bayesian estimation of amikacin exposure in critically ill septic patients88
Monit., Volume 32, Issue 6, Number 756, p.749- 756 (2010) Keywords: 0 a Adult Aged Aged,80 and over Agent Agents Amikacin an analysi analysis Anti-Bacterial Agents Antibiotic approach approaches article ...
Synthetic EthR inhibitors boost antituberculous activity of ethionamide36849
Delcroix,G.; Frenois,F.; Aumercier,M.; Locht,C.; Villeret,V.; Deprez,B.; Baulard,A.R. Source: Nat.Med., Volume 15, Issue 5, Number 544, p.537- 544 (2009) Keywords: 0 a Activity Agent Agents Animals antagonists ...
Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.
Mathema, Barun; Baulard, Alain; Kreiswirth, Barry N; Bifani, Pablo Source: Antimicrob Agents Chemother, Volume 53, Issue 5, p.2100-9 (2009) Keywords: Aminosalicylic Acid Antitubercular Agents Bacterial ...
Metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation.
Voet, Marleen; Jeroen Wagemans; Pieter-Jan Ceyssens; Noben, Jean-Paul; Aertsen, Abram; Lavigne, Rob Source: Cell Rep, Volume 38, Issue 7 (2022) Keywords: Acetyltransferases Anti-Bacterial Agents Bacterial ...