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Microbial quality analysis of falsified medicines seized by controling agencies
set out to see if these products were contaminated with bacteria and fungi and performed enumeration tests. Next, we also conducted a series of microbiological assays on those bacterial strains that ...
Development of a data-intensive centralized system for surveillance and outbreak investigation of bacterial pathogens using whole-genome sequencing
when the sequencing is ongoing, reducing total turnover time. The implementation of the protocol was coupled with an extensive performance evaluation to provide concrete guidelines for setting up ...
Tick-borne diseases in Belgium: The incidence and economic burden of Lyme borreliosis and the occurrence of other tick-borne infections
have remained. This thesis aims to contribute to the assessment of the burden of LB in Belgium, amongst others, by setting up a prospective cohort study. This work resulted in estimations of the ...
Development of a genoserotyping system for the identification of Salmonella serotypes
accuracy, cost- and time-effectiveness of Salmonella serotype identification in a routine setting. The 4 MOL- PCR assays developed here are up to 7.5 less expensive than the classical methods and they are ...
DETERMINATION OF ALLERGENIC FRAGRANCE INGREDIENTS IN FEMININE ABSORBENT HYGIENE PRODUCTS AND LUBRICANTS
matrix-effect in AHP s was reduced with the use of 1-fluoronapthalene as an internal standard (IS) and matrix-matched calibration for quantification purposes. A relative bias was set at 15%, that was met by each ...
Detection and risk evaluation of counterfeit medicines based on physico-chemical properties: the fingerprint and chemometrics approach
fingerprints for a Viagra® and a Cialis® sample set. These fingerprints were included in the chemometric data analysis, aiming to test whether PDA and MS are complementary detection techniques. This extensive ...
Ontwikkeling van een screeningsmethode voor de detectie van slimming agents en PDE5-inhibitoren in illegale voedingssupplementen met behulp van Phase Optimized Liquid Chromatography (POP-LC)
bredere range aan polariteit te omvatten. Een eerste screeningsmethode wordt ontwikkeld voor een set van moleculen met een gewichtsreducerend effect. De uiteindelijke screeningsmethode wordt bekomen door ...
Development of a generic and open source Incidence-Prevalence-Mortality model for the assessment of chronic disease epidemiology
cubic smoothing splines and the tolerance limits of the optimization procedure. Using the breast cancer data set of the Netherlands, the properties of the DisMod() function was shown. Additional outputs ...
Exploring the added value of Whole Genome Sequencing in routine and pandemic viral surveillance
it is a challenge to distinguish these low-frequency variants from the experimental errors while considering the limiting circumstances of a routine setting where it is improbable that samples will be ...