Yellow fever virus (YFV) neutralizing antibodies

Test description

Detection of neutralising antibodies to yellow fever virus.

Purpose of the test

Evaluation of post-vaccination protection in defined groups (see section3. Criteria).

Criteria for performing this test

• Checking post-vaccination status is unnecessary for most individuals, as in people with normal immunity, a single yellow fever vaccination provides lifelong protection. For some subpopulations in whom there is doubt whether the immune response is optimal (as, for example, in young children), a one-time booster is recommended (expert opinion). In these people, determination of neutralising antibodies is therefore also unnecessary.
• Detection of neutralising antibodies is only recommended in:
  • people in whom immunosuppressive medication was temporarily stopped to receive a yellow fever vaccination. In this case, a check-up 1 to 2 months after vaccination is recommended (expert opinion)
  • individuals with permanently reduced immunity who need a booster but cannot receive it for medical reasons.
• Prior consultation between the responsible specialist and an ITG vaccination expert is desirable.
• Indicate the date (year) of the last yellow fever vaccination and motivation on the request form.

Instructions for the sample

• Serum
• Minimum quantity: 1.5 ml
• Store at 4°C

Instructions for transport

• Samples can be shipped at room temperature.
• Transit time should be kept as short as possible (Avoid transportation during weekends or holidays).

Unacceptable request

Requests without motivation.

Turn around time (and frequency of analysis)

Average: 16 days.

Reporting of test results

The report will be sent by fax, post or e-mail.