Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines.

Last updated on 23-8-2019 by Anonymous (not verified)

Peer reviewed scientific article

English

Abstract:

INTRODUCTION: Pathogen recognition receptors (PRRs) recognize pathogen-associated molecular patterns, triggering the induction of inflammatory innate responses and contributing to the development of specific adaptive immune responses. Novel adjuvants have been developed based on agonists of PRRs. Areas covered: Lipid pathogen-associated molecular patterns (PAMPs) present in the cell wall of mycobacteria are revised, with emphasis on agonists of C-type lectin receptors, signaling pathways, and preclinical data supporting their use as novel adjuvants inducing cell-mediated immune responses. T…

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