Pyrrolizidine alkaloids in herbs and related foodstuffs (PASHERBS)

Last updated on 23-8-2019 by Anonymous (not verified)

Sci. report, recommendat°, guidance doc., directive, monograph




Pyrrolizidine alkaloids (PAs) and their N-oxides (PANOs) are natural toxins, exclusively biosynthesized by a wide variety of plant species (>6000). They are secondary plant metabolites against herbivores and are believed to be one of the most widely spread natural toxins. PAs and PANOs can become a significant public human health problem from the intake of contaminated food of botanical or animal origin. Human poisoning cases have been documented; they are characterized by acute and chronic liver damage, pulmonary hypertension, cardiac or kidneys injuries, and can lead to death. However,…

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