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Attenuation of RNA viruses by redirecting their evolution in sequence space.
influenza A viruses to redirect their evolutionary trajectories towards detrimental regions in sequence space. Specifically, viral genomes were engineered to harbour more serine and leucine codons with ...
Us3 and Us9 proteins contribute to the stromal invasion of bovine herpesvirus 1 in the respiratory mucosa.
genital disorders and abortion. BHV-1 is able to spread quickly in a plaque-wise manner and invade by breaching the basement membrane (BM) barrier in the respiratory mucosa. BHV-1 Us3, a serine ...
Biochemical analysis of the NAD+-dependent malate dehydrogenase, a substrate of several serine/threonine protein kinases of Mycobacterium tuberculosis
Public-health recombinant Research Research Support Residue result results Role SB- IM Tuberculosis Abstract: PknD is one of the eleven eukaryotic-like serine/threonine protein kinases (STPK s) of Mycobacterium ...
Protective effect of different anti-rabies virus VHH constructs against rabies disease in mice.
The therapeutic effect depended on the dose, affinity and brain and plasma half-life of the VHH construct. Increasing the affinity by combining two VHH with a glycine-serine linker into bivalent or ...