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Clinical performance of the novel full-genotyping OncoPredict HPV Quantitative Typing assay using the VALGENT framework.
OncoPredict HPV QT (index test) for the detection of CIN2 + was assessed relative to the GP5 +/6+ Enzyme ImmunoAssay (GP5 +/6+ EIA) (comparator test), using noninferiority criteria. Intra- and interlaboratory ...
Evaluation of the clinical performance of OncoPredict HPV® SCR assay within the VALGENT‐2 framework
Intra- and interlaboratory reproducibility of the index was evaluated by overall concordance and Cohen’s kappa, using a sub-population (n = 526). Relative sensitivity and specificity for CIN2 + of the ...
Poor timing and failure of source control are risk factors for mortality in critically ill patients with secondary peritonitis.
including 2621 adult ICU patients with intra-abdominal infection in 306 ICU s from 42 countries. Time-till-source control intervention was calculated as from time of diagnosis and classified into ‘emergency’ ...
Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study.
OBJECTIVE: To describe epidemiology and age-related mortality in critically ill older adults with intra-abdominal infection. METHODS: A secondary analysis was undertaken of a prospective, multi-national, ...
Whole-Genome Sequence Approach and Phylogenomic Stratification Improve the Association Analysis of Mutations With Patient Data in Influenza Surveillance.
mainly focused on the hemagglutinin gene. Whole-genome sequencing (WGS) enables tracking mutations across all influenza segments allowing a better understanding of the epidemiological effects of intra- and ...
Development and validation of a microfluidic multiplex immunoassay for the determination of levels and avidity of serum antibodies to tetanus, diphtheria and pertussis antigens.
microfluidic channels of the assay cartridges of the system. The developed assay showed very good sensitivity, specificity, and intra- and inter-assay coefficients of variation (CV s for the different antigens ...
Intra- and inter-laboratory comparison of mDixon and FastFung broths for Malassezia antifungal susceptibility testing.
agreement (EA) between the two assays, and the intra- and inter-laboratory agreement of each assay were assessed. RESULTS: The MIC data obtained in our study were comparable to those reported in the ...
Development of a dot-blot assay for the detection of mould-specific IgE in the Belgian population
“major sensitization” defined as the strongest response against a single mould species was calculated. Results Intra- and inter-assay variations were both below 20%, and the positivity threshold of the ...
Whole-genome-based phylogenomic analysis of the Belgian 2016-2017 influenza A(H3N2) outbreak season allows improved surveillance.
classification. Moreover, Bayesian inference via beast facilitated reassortment detection by both manual inspection and computational methods, detecting intra-subtype reassortants at an estimated rate of 15 %. ...