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Potential (co-)contamination of dairy milk with AFM1 and MC-LR and their synergistic interaction in inducing mitochondrial dysfunction in HepG2 cells.
milk Mitochondria Tandem Mass Spectrometry Abstract: Several toxic metabolites, such as aflatoxin M1 (AFM1), are known to contaminate dairy milk. However, as mentioned in an external EFSA report, there ...
Sphaeropsidin A C15-C16 Cross-Metathesis Analogues with Potent Anticancer Activity.
Drug Drug Screening Assays, Antitumor Humans Molecular Structure Pyrenes Structure-Activity Relationship Abstract: We recently discovered that sphaeropsidin A (SphA), a fungal metabolite from Diplodia ...
Experimental accumulation and depuration kinetics and natural occurrence of microcystin-LR in basil (Ocimum basilicum L.).
a hepatotoxic metabolite that naturally occurs during some cyanobacterial blooms in eutrophic waterbodies, and irrigation of edible plants with MC- LR-contaminated water causes bioaccumulation of the toxin. ...
Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.
of structurally diverse secondary metabolites with toxic potential has been identified, but occurrence and relative proportion of the different metabolites in complex mixtures depend on strain, ...
Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial
observed for rebaudioside A in mice, they have been attributed to the metabolites steviol and steviol glucuronide. We aimed to characterize the pharmacokinetic and pharmacodynamic properties of rebaudioside ...
Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market
LC-MS/MS oleandrin plant toxins urine VALIDATION Abstract: Cardiac glycosides (CG s) are naturally occurring plant secondary metabolites that can be toxic to humans and animals. The aim of this work was to ...
Biological monitoring of exposure to pesticide residues among Belgian florists
compounds and metabolites) in their urines. A total of 42 urine samples (24-h urines) were collected from florists during their professional activities, on the three most important commercial periods. The ...
Pyrrolizidine alkaloids in food… the good, the bad and the ugly!
biosynthesized by a wide variety of plant species (> 6000), the great majority of them belong to the Asteraceae, Fabaceae and Boraginaceae families. PA s are typical plant secondary metabolites against ...
Insights into In Vivo Absolute Oral Bioavailability, Biotransformation, and Toxicokinetics of Zearalenone, α-Zearalenol, β-Zearalenol, Zearalenone-14-glucoside, and Zearalenone-14-sulfate in Pigs
oral administration of ZEN and its modified forms. Systemic plasma concentrations of the administered toxins and their metabolites were quantified and further processed via tailor-made compartmental ...
Monitoring of pyrrolizidine alkaloids in beehive products and derivatives on the Belgian market
secondary plant metabolites thought to be found in approximately 3% of the flowering plants worldwide and exhibiting hepatotoxic properties to humans. As a consequence, beehive products are prone to be ...