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Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
constructed and sequenced using the HiSeq technology (Illumina®). Reads were mapped to the reference genome and normalized read counts were calculated per gene. Results: For each drug a specific ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
bead-beating in TRI zol and the Direct-Zol purification kit. After quality control, the extracts were fragmented, barcoded and pooled, cDNA libraries were constructed and sequenced using the HiSeq technology ...
Transcriptional profiling of Mycobacterium tuberculosis suggests respiratory poisoning upon exposure to delamanid
a pressure of the recently approved delamanid is investigated. Total RNA sequencing revealed that the response to this bicyclic nitroimidazole shows many similarities with pretomanid, an anti-tuberculous drug ...