Rubella virus: Pre-natal diagnosis of congenital Rubella infection

Description of tests

• RNA of rubella virus is detected by real-time PCR on amniotic fluid.
• The sensitivity of this PCR for the diagnosis of congenital Rubella is estimated to be 90%.

Purpose of testing

To detect Rubella virus on amniotic fluid in a pregnant woman to diagnose possible congenital Rubella infection in the foetus.

Criteria for performing this test

• The reference centre performs PCR on amniotic fluid from pregnant patients at risk of congenital Rubella.
• Application forms must be completed in full.

Instructions for samples and transport

Amniotic fluid: 2 ml, stored at 4°C; ship at room temperature no later than the day after collection.

Unacceptable requests

• Incomplete request form
• Sample not suitable for analysis
• Incorrect transport/storage. 

Turn around time

Response time: 1 to 5 working days (contact the laboratory in case of emergency)

Reporting of test results

The laboratory reports the results and comments and sends it to the requesting laboratory by post or fax.