2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus.

Last updated on 22-8-2019 by Anonymous (not verified)

Peer reviewed scientific article



We report on the potent and selective in vitro antiviral activity of 2’-C-methylcytidine (2’-C-MetCyt) against foot-and-mouth disease virus (FMDV). FMDV belongs to the Picornaviridae and has the potential to cause devastating epidemics in livestock. The 50% and 90% effective concentrations (EC50 and EC90) for inhibition of the FMDV-induced cytopathic effect (CPE) formation were 6.4+/-3.8 and 10.8+/-5.4 microM. Comparable EC50 values for inhibition of viral RNA synthesis were observed. Treatment of FMDV-infected BHK-21 cells with 77 microM 2’-C-MetCyt resulted in a (1.6-3.2)x10(3)-fold reduc…

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