RNA-based drug susceptibility testing of Mycobacterium tuberculosis

Last updated on 6-12-2018 by Pieter-Jan Ceyssens

Scientific poster, presentation or proceeding

English

SCIENSANO

Abstract:

To counter the long turnaround time of standard phenotypic Drug Susceptibility Testing (DST) of M. tuberculosis (Mtb), multiple DNA-based methods were successfully introduced over the last years. Although these are fast and sensitive, they (a) are based on the knowledge on resistance mutations which is limited for especially 2nd-line and new drugs, (b) do not distinguish living from death cells, (c) ignore all intrinsic resistance mechanisms like efflux pump overexpression, and (d) ignore the multifactorial influence of compensatory mutations. Here, we introduce a next-generation diagnostic…

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