Last updated on 23-8-2019 by Anonymous (not verified)
Keywords
Abstract:
Tuberculosis (TB) is the most deadly infectious disease worldwide. To reduce TB incidence and counter the
spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the
transcriptional response of two Mycobacterium tuberculosis strains to a pressure of the recently approved delamanid
is investigated. Total RNA sequencing revealed that the response to this bicyclic nitroimidazole shows
many similarities with pretomanid, an anti-tuberculous drug from the same class. Although delamanid is found
to inhibit cell wall synthesis, t…