Résultats de la recherche - 4 results
Para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis33991
genetics identification im Institute IS IT journal Laboratories mechanism metabolism Mutation Mycobacterium Mycobacterium tuberculosis Pa PAS pharmacokinetics pharmacology prevent Prodrugs protein Proteins ...
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
Models,Molecular Mycobacterium Mycobacterium tuberculosis ON Oxadiazoles pathogen Pharmacokinetic pharmacokinetics Piperidines PROCESSES Prodrugs protein Proteins Repressor Proteins Research Research Support SB- IM ...
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate ...
The small-molecule SMARt751 reverses resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Transl Med, Volume 14, Issue 643 (2022) Keywords: Animals Antitubercular Agents Ethionamide mice Mycobacterium tuberculosis Prodrugs Tuberculosis Abstract: The sensitivity of, the pathogen that causes ...