Résultats de la recherche - 161 results
Development and implementation of novel liquid biopsy NGS panels via the OncNGS precommercial procurement (PCP) initiative
conducted an open market consultation, and launched a call for tender. Suppliers were invited to develop an end-to-end, Conformité Européenne In Vitro Diagnostic (CE- IVD)-compliant solution integrating wet ...
Physicochemical characterization and genotoxicity assessment of nanomaterials using new approach methodologies
the characterized iron (hydr)oxides and copper oxides. These cover both the in vitro genotoxicity tests that are currently recommended by EFSA which are adapted for nanomaterials and materials ...
Assessment of receptor-mediated activity (AhR and ERα), mutagenicity, and teratogenicity of metal shredder wastes in Wallonia, Belgium.
chemical and biological techniques was used, to better reflect the risks to health and the environment. The samples investigated induced significant in vitro aryl hydrocarbon receptor (AhR) agonistic ...
Advancing automated identification of airborne fungal spores: Guidelines for cultivation and reference dataset creation
classify airborne fungal spores. Critical aspects such as access to reference fungal species, in vitro cultivation, sporulation yield, clean spore isolation, dry aerosolization, and dataset cleaning have ...
Maintaining the quality of vaccines through the use of standards: Current challenges and future opportunities.
ever-increasing complexity, diversity, and number of vaccine products as well as increasing efforts to replace animal-based potency tests with in vitro assays that measure relevant quality attributes. As such, ...
EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects
submitted to a thorough physicochemical characterisation. A battery of in vitro tests was used to provide insight into NC hazard and mode of action according to a tiered approach, which lead to selection of ...
Pyrogen testing of phage therapeutic products
is pivotal to limit the risk of non-endotoxin contamination. These pyrogens can be detected by the monocyte activation test (MAT), which employs human blood cells to quantify pyrogenicity in vitro. In ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.
towards a more human-relevant in vitro genotoxicity testing strategy without the use of experimental animals. Health Topics: Health and environment Santé et environnement Gezondheid en milieu Service: ...
Rational arguments for regulatory acceptance of consistency testing: benefits of non-animal testing over release testing of vaccines.
Issue 1, Number 377 (2023) Abstract: INTRODUCTION: There are rational arguments to replace existing in vivo potency and safety assays for batch release testing of vaccines with more advanced non-animal ...
Development of a Droplet Digital PCR to Monitor SARS-CoV-2 Omicron Variant BA.2 in Wastewater Samples
used as a complementary method to other SARS-CoV-2 surveillance systems. It allows the emergence and spread of infections and SARS-CoV-2 variants to be monitored in time and place. This study presents an ...