Résultats de la recherche - 23 results
Chemometrics and the identification of counterfeit medicines-A review.
of actual case studies dealing with verifying the authenticity of selected medicines supported by different chemometric approaches. In particular, a general data processing workflow is discussed with ...
Childhood leukaemia near nuclear sites in Belgium, 2002-2008.
hypothesis of a gradient in leukaemia incidence with increasing levels of surrogate exposures was explored by means of focused hypothesis tests and generalized additive models. For the surrogate exposures, ...
Detection and risk evaluation of counterfeit medicines based on physico-chemical properties: the fingerprint and chemometrics approach
efficient way. In general, it can be concluded that fingerprinting proves to be a useful strategy for the screening of counterfeit medicines and adulterated products. Based on the desired information, ...
The Monte Carlo validation framework for the discriminant partial least squares model extended with variable selection methods applied to authenticity studies of Viagra® based on chromatographic impurity profiles.
Counterfeit Drugs Discriminant Analysis Least-Squares Analysis Monte Carlo Method Sildenafil Citrate Abstract: The aim of this work was to develop a general framework for the validation of discriminant models ...
Testing of complementarity of PDA and MS detectors using chromatographic fingerprinting of genuine and counterfeit samples containing sildenafil citrate.
interesting for the characterization of counterfeit drugs in developing countries. However, in general, the combination of PDA and MS data (254 nm_MS1) is preferred due to less classification errors between the ...
First Belgian national EQA for special stains in histopathology
the secondsurvey (2015) for special stains in histopathology.Aim:The two surveys aimed at assessing laboratory and method performance of the Belgian licensed pathologylaboratories. General quality of ...
Analysis of illegal peptide biopharmaceuticals frequently encountered by controlling agencies.
distributions of these substances. At their request, suspected protein and peptide preparations are analysed in our Official Medicines Control Laboratory (OMCL). It stands to reason that a general screening ...
General considerations on the biosafety of virus-derived vectors used in gene therapy and vaccination.
introductory paper gathers general considerations on the biosafety of virus-derived vectors that are used in human gene therapy and/or vaccination. The importance to assess the potential risks for human health ...
Chromatography in the detection and characterization of illegal pharmaceutical preparations.
intends to give a general overview of the techniques described in literature to characterize counterfeit and illegal pharmaceutical preparations, focusing on the role of chromatographic techniques with ...
Evaluation of the residual solvent content of counterfeit tablets and capsules.
counterfeit samples had higher residual solvent contents compared to the genuine products. A more diverse range of residual solvents was found as well as higher concentrations. In general these concentrations ...