Population Analysis of O26 Shiga Toxin-Producing Causing Hemolytic Uremic Syndrome in Italy, 1989-2020, Through Whole Genome Sequencing.

Last updated on 12-9-2022 by Sigrid De Keersmaecker

Public Access


Peer reviewed scientific article



Shiga toxin-producing (STEC) belonging to the O26 serogroup represent an important cause of Hemolitic Uremic Syndrome (HUS) in children worldwide. The localization of STEC virulence genes on mobile genetic elements allowed the emergence of clones showing different assets of this accessory genomic fraction. A novel O26 STEC clone belonging to Sequence Type (ST) 29 and harboring , and plasmid-borne genes has emerged and spread in Europe since the mid-1990s, while another ST29 clone positive for and lacking plasmid-borne virulence genes was recently described as emerging in France. In Italy, O…

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