Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

Last updated on 23-8-2019 by Anonymous (not verified)

Peer reviewed scientific article

English

SCIENSANO

Authors

The CRyPTIC Consortium and the 100000 Genomes Project; Allix-Béguec, Caroline; Arandjelovic, Irena; Bi, Lijun; Beckert, Patrick; Bonnet, Maryline; Bradley, Phelim; Andrea Cabibbe; Cancino-Muñoz, Irving; Mark J. Caulfield; Chaiprasert, Angkana; Cirillo, Daniela; Clifton, David; Comas, Iñaki; Derrick W Crook; Maria R De Filippo; De Neeling, Han; Diel, Roland; Francis A. Drobniewski; Faksri, Kiatichai; Maha R. Farhat; Fleming, Joy; Fowler, Philip; Tom A. Fowler; Gao, Qian; Gardy, Jennifer; Gascoyne-Binzi, Deborah; Gibertoni-Cruz, Ana-Luiza; Ana Gil-Brusola; Golubchik, Tanya; Gonzalo, Ximena; Grandjean, Louis; Guangxue, He; Jennifer L. Guthrie; Hoosdally, Sarah; Hunt, Martin; Iqbal, Zamin; Ismail, Nazir; Johnston, James; Khanzada, Faisal; Khor, Chiea; Thomas A. Kohl; Kong, Clare; Lipworth, Sam; Liu, Qingyun; Maphalala, Gugu; Martinez, Elena; Vanessa Mathys; Merker, Matthias; Miotto, Paolo; Mistry, Nerges; David A.J. Moore; Murray, Megan; Niemann, Stefan; Rick T.-H. Ong; Tim E.A. Peto; James E. Posey; Prammananan, Therdsak; Pym, Alexander; Rodrigues, Camilla; Mabel Rodrigues; Timothy Rodwell; Gian M. Rossolini; Sánchez Padilla, Elisabeth; Schito, Marco; Shen, Xin; Shendure, Jay; Sintchenko, Vitali; Sloutsky, Alex; Smith, E. Grace; Snyder, Matthew; Karine Soetaert; Angela M. Starks; Supply, Philip; Suriyapol, Prapat; Tahseen, Sabira; Tang, Patrick; Teo, Yik-Ying; Thuong N.T. Thuong; Thwaites, Guy; Tortoli, Enrico; V. Omar, Shaheed; van Soolingen, Dick; Walker, A. Sarah; Timothy M. Walker; Mark Wilcox; Daniel J. Wilson; Wyllie, David; Yang, Yang; Zhang, Hongtai; Zhao, Yanlin; Zhu, Baoli

Keywords

Abstract:

BACKGROUND: The World Health Organization recommends drug-susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes. Whether DNA sequencing can be used to accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear.METHODS: We obtained whole-genome sequences and associated phenotypes of resistance or susceptibility to the first-line antituberculosis drugs isoniazid, rifampin, ethambutol, and pyrazinamide for isolates from 16 countries across six continents. For e…

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