Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

Last updated on 23-8-2019 by Anonymous (non vérifié)

Peer reviewed scientific article

Anglais

SCIENSANO

Auteurs

The CRyPTIC Consortium and the 100000 Genomes Project; Allix-Béguec, Caroline; Irena Arandjelovic; Bi, Lijun; Patrick Beckert; Maryline Bonnet; Bradley, Phelim; Andrea Cabibbe; Cancino-Muñoz, Irving; Mark J. Caulfield; Angkana Chaiprasert; Daniela Cirillo; David Clifton; Comas, Iñaki; Derrick W Crook; Maria R De Filippo; Han De Neeling; Roland Diel; Francis A. Drobniewski; Faksri, Kiatichai; Maha R. Farhat; Joy Fleming; Philip Fowler; Tom A. Fowler; Gao, Qian; Jennifer Gardy; Deborah Gascoyne-Binzi; Gibertoni-Cruz, Ana-Luiza; Ana Gil-Brusola; Tanya Golubchik; Ximena Gonzalo; Louis Grandjean; Guangxue, He; Jennifer L. Guthrie; Sarah Hoosdally; Martin Hunt; Zamin Iqbal; Ismail, Nazir; James Johnston; Faisal Khanzada; Chiea Khor; Thomas A. Kohl; Clare Kong; Sam Lipworth; Liu, Qingyun; Maphalala, Gugu; Elena Martinez; Vanessa Mathys; Matthias Merker; Paolo Miotto; Mistry, Nerges; David A.J. Moore; Megan Murray; Stefan Niemann; Rick T.-H. Ong; Tim E.A. Peto; James E. Posey; Prammananan, Therdsak; Alexander Pym; Camilla Rodrigues; Mabel Rodrigues; Timothy Rodwell; Gian M. Rossolini; Elisabeth Sánchez Padilla; Marco Schito; Xin Shen; Jay Shendure; Vitali Sintchenko; Alex Sloutsky; Grace E. Smith; Matthew Snyder; Karine Soetaert; Angela M. Starks; Supply, Philip; Suriyapol, Prapat; Sabira Tahseen; Patrick Tang; Teo, Yik-Ying; Thuong N.T. Thuong; Guy Thwaites; Tortoli, Enrico; Shaheed V. Omar; Dick van Soolingen; Sarah A. Walker; Timothy M. Walker; Mark Wilcox; Daniel J. Wilson; David Wyllie; Yang, Yang; Zhang, Hongtai; Zhao, Yanlin; Zhu, Baoli

Mots-clés

Résumé:

BACKGROUND: The World Health Organization recommends drug-susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes. Whether DNA sequencing can be used to accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear.METHODS: We obtained whole-genome sequences and associated phenotypes of resistance or susceptibility to the first-line antituberculosis drugs isoniazid, rifampin, ethambutol, and pyrazinamide for isolates from 16 countries across six continents. For e…

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