HYPIEND - Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations

Last updated on 9-2-2024 by Lieke Vervoort
Project duration:
January 1, 2024
-
December 31, 2028

In short

Exposure to multiple endocrine disrupting chemicals (EDCs) is known to interfere with the development and function of the endocrine system. This interaction is particularly worrying at developmental stages in life, such as the perinatal period and puberty. Beyond research to improve our understanding of the mechanisms of action of EDCs, the HYPIEND project tests the value of intervention strategies, e.g. plastic free canteens, raising awareness of EDC among parents and activities with children, aimed at  minimising exposure during the perinatal and prepubertal periods.
 

Project description

The HYPIEND consortium includes 14 teams coming from Spain, the Netherlands, Belgium, Sweden, Poland, Italy, Switzerland and The United Kingdom, who have joined forces to improve the knowledge of the mechanisms of action of exposure to mixture of endocrine disrupting chemicals (EDCs). Indeed, despite current knowledge of the actions of EDCs (individually) on the endocrine system, a global and holistic understanding of the impact on the Hypothalamus-Pituitary (HP) axis is still lacking. HYPIEND aims to understand the effects of co-exposures to EDCs in the function and epigenetic programming of the HP axis in order to define intervention strategies aimed at minimising exposure and consequences on the neuroendocrine system during the perinatal and prepubertal periods, both being known as windows of susceptibility during which exposures are of particular importance for health effects.

In a first step, we will carry out in vitro analyses, as well as in silico and in vivo, as well as on new organoid-based organ-on-a-chip (OOAC) models. These new OOAC technologies aim to reproduce the structure and function of human organs and tissues in a controlled, miniaturised environment, enabling different functions to be studied, in this case the HP axis. 

On the basis of these investigations, two intervention studies aimed at minimising exposure to EDC will be conducted in children at the perinatal and prepubertal stages. Sciensano is more specifically involved in the work on prepubertal children, as well as in risk exposure evaluation and risk modelling in relation to EDCs. 
 

Sciensano's project investigator(s):

Service(s) working on this project

Partners

Biotza Gutierrez Arechederra

Financial Source

Associated Health Topics

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