Is aggregated synthetic amorphous silica toxicologically relevant?

Last updated on 20-1-2021 by Jill Alexandre

Public Access


Peer reviewed scientific article


Article written during project(s) : 


Background: The regulatory definition(s) of nanomaterials (NMs) frequently uses the term ‘agglomerates and aggregates’ (AA) despite the paucity of evidence that AA are significantly relevant from a nanotoxicological perspective.This knowledge gap greatly afects the safety assessment and regulation of NMs, such as synthetic amorphous silica (SAS). SAS is used in a large panel of industrial applications. They are primarily produced as nanosized particles (1–100 nm in diameter) and considered safe as they form large aggregates (> 100 nm) during the production process. So far, it is indee…

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