Last updated on 12-12-2020 by Kim Van Roey
Peer reviewed scientific article
Anglais
SCIENSANO
Auteurs
Holger Dinkel; Michael, Sushama; Robert J Weatheritt; Norman E Davey; Kim Van Roey; Brigitte Altenberg; Grischa Toedt; Bora Uyar; Markus Seiler; Aidan Budd; Lisa Jödicke; Marcel A Dammert; Christian Schroeter; Maria Hammer; Tobias Schmidt; Peter Jehl; Caroline McGuigan; Magdalena Dymecka; Claudia Chica; Katja Luck; Allegra Via; Andrew Chatr-Aryamontri; Niall Haslam; Gleb Grebnev; Richard J Edwards; Michel O Steinmetz; Heike Meiselbach; Francesca Diella; Toby J GibsonMots-clés
Résumé:
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.e…