Factitiously low urate recoveries in control sera with the Beckman Synchron Systems

Last updated on 22-8-2019 by Anonymous (non vérifié)

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Peer reviewed scientific article



In the Belgian national external quality assessment scheme, we observed significantly lowered recoveries for urate in the group of Beckman Synchron users in comparison with the overall median values of the uricase/peroxidase colorimetric methods. These effects were linked to control sera of some manufacturers and we could demonstrate that these sera contained large amounts of pyridoxal-5-phosphate (PLP) as activator for transaminases. By spiking normal human serum with increasing PLP concentrations from 62.5 to 1000 mumol l-1, we observed a decrease in the urate recovery from 125 mumol l-1 …

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